ECE2014 Poster Presentations Adrenal cortex (56 abstracts)
Are small adrenal incidentalomas solely a radiological finding?
Mehmet Asik 1 , Mustafa Eroglu 1 , Hakan Turkon 1 , Emine Binnetoglu 1 , Fahri Gunes 1 , Hacer Sen 1 , Gokhan Erbag 1 , Yeliz Yilmaz 1 , Mustafa Sahin 2 & Kubilay Ukinc 1
1Çanakkale Onsekiz Mart University, Çanakkale, Turkey; 2Ankara University, Ankara, Turkey.
Introduction: The criteria defining the threshold size of adrenal incidentaloma (AI) are >1 cm diameter. However, data about AI ≤1 cm diameter is scant. The aim of this study is to evaluate function of adrenal masses ≤1 cm and to compare them with adrenal masses >1 cm as well as to understand the possible utility of determining salivary cortisol in diagnosis of SCS in patients with AI.
Method: The study included 137 consecutive patients with AI (38 and 99 AI at ≤1 and >1 respectively).
Results: SCS was 5.3 and 17.2% in AI ≤1 cm and >1 m diameter, respectively. The patients with >1 cm AI had a higher prevalence of SCS and primary hyperaldosteronism than patients with >1 cm AI did, but they did not differ significantly. The prevalence of diabetes and hypertension was high both in non-functional AI with ≤1 and >1 patients and showed no significant difference between two groups. Using a cut-off of 0.33 μg/dl for midnight salivary cortisol (MNSC), sensitivity, specificity, values of positive and negative predictivity for diagnosis of SCS were 58, 86, 40.7 and 91.8% respectively.
Conclusion: The AI ≤1 cm harboured SCS as was the case in AI >1 cm. Similar to AI >1 cm, non-functional AI ≤1 cm also had higher prevalence of diabetes and hypertension. Furthermore, MNSC in patients with AI was found comparable with midnight serum cortisol in diagnoses of SCS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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