Endocrine Abstracts

Autopsy studies report a reservoir of small, occult, and undiagnosed breast cancers in up to 15.6% of 40–80-year-old women dying from unrelated causes. Modeling of the biologic behavior of these occult tumors facilitates interpretation of the effects of hormone therapy in menopausal women. We used iterative and mathematical techniques to develop a model of occult tumor growth (OTG) whose parameters included prevalence, effective doubling time (EDT), and detection threshol...