Endocrine Abstracts

Introduction: The transcription factor 7-like 2 gene (TCF7L2) has the strongest effect on the risk of type 2 diabetes but the mechanism for this is not fully understood. Some genetic variants are associated with pancreatic B-cell function and some single nucleotide polymorphisms show a significant correlation with obesity. The aim of the study was to analyze whether TCF7L2 variants may influence body weight and body fat content, as well as postprandial glucose metabolism in no...

Background: Presently, a great deal of attention is being paid to investigation of pleiotropic effects of oral antidiabetic drugs. Several recent animal studies have suggested that vildagliptin and metformin could play some positive role in preventing the evolvement of diabetic nephropathy.Aim: This pilot study, concerned with high-fat fed heminephrectomized streptozotocin (STZ)-induced diabetic rats, aimed to evaluate and compare the effects of metformi...

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

Background: Endothelial progenitor cells (EPCs) play an important role in neovascularization and endothelial regeneration, and the number and function of circulating EPCs is decreased in patients with diabetic retinopathy and type 1 diabetic nephropathy. However, the number and function of EPCs in patients with type 2 diabetes nephropathy is unknown.Methods: Participants were divided into three groups: 1) type 2 diabetes with overt nephropathy (DN group,...

Background: Lipoprotein-associated phospholipase A2 (LpPLA2) is known as an emerging marker of coronary artery disease (CAD). However its role and levels have not been documented clearly in diabetic patients with CAD in Indians. The aim of this study was to explore the association of LpplA2 levels between diabetic and non-diabetic patients with CAD and compare it with other established markers like hs-CRP.Methods: Sixty individuals with angiographically ...