Endocrine Abstracts

In this session, the most recent publications related to the topic and published in 2013/2014 will be discussed and set into a clinical and problem-oriented context. In primary aldosteronism three Nature genetics papers have elucidated the genetic basis of aldosterone-producing adenomas. In addition, an important AVS expert consensus has been published (Hypertension 2014). Also, in 2014, a revised Endocrine Society Practice Guidline for primary aldosteronism is expected (JCEM). In adrenal Cushing’s syndrome three manuscripts published in the NEJM have elucidated the specific pathophysiologic mechanism of ACTH independent macronodular adrenal hyperplasia and sporadic cortisol producing adenomas. A systematic review (JCEM) has highlighted the beneficial outcome of bilateral adrenalectomy for Cushing’s disease in a large series of publications. We will discuss a manuscript (JCEM) reporting the use of the monoclonal CD20 antibody rituximap to induce remission in freshly diagnosed Addison’s disease. Also, a clinical study (EJE) comparing IV and sc hydrocortisone for adrenal crisis will be reported. Finally we will discuss cost effectiveness of adrenalectomy vs watchfull waiting in adrenal incidentaomas of 4 cm size and above (Surgery).