Endocrine Abstracts

Objective: To investigate the impact of the serum testosterone on the metabolic syndrome (MS) in young and middle-aged men with type 2 diabetes mellitus (T2DM).

Methods: A total of 220 young-and middle-aged (18–50) men with T2DM were recruited in this study and were divided into four groups based on serum testosterone quartile. General information, smoking history and anthropometry data were collected. Fasting glucose, fasting insulin, blood fat and HbA1c were detected. BMI and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated.

Results: With the increasing of testosterone concentration, the incidence of MS was decreased X²=8.748, P=0.033), together with the decrease of age, smoking, course of T2DM, waist circumference, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), HbA1c, HOMA-IR, total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDL-C); (all P<0.05 or P<0.01), and the increase of cholesterol (HDL-C); (F=1.928, P=0.126). Spearman correlation analyze indicated that serum testosterone was negatively correlated with age (r=−0.452), smoking (r=−0.543), course of T2DM (r=−0.314), waist circumference (r=−0.417), BMI (r=−0.362), SBP (r=−0.268), DBP (r=−0.275), HbA1c (r=−0.329), HOMA-IR (r=−0.418), TG (r=−0.267), TC (r=−0.259), LDL-C (r=−0.324)(all P<0.05 or P<0.01), and positively correlated with HDL-C (r=0.078, P=0.628). Logistic regression analyze indicated that serum testosterone was the protective factor of MS in young and middle-aged men with T2DM (OR=0.479, 95%, CI, 0.249–0.936, P<0.01).After the adjustment of age, smoking, course of T2DM, HOMA-IR and HbA1c, the OR was 0.759(95%CI:0.598–0.963 P<0.05).

Conclusion: The serum testosterone in young and middle-aged men with T2DM was negatively correlated with MS. Low serum testosterone may be an independent risk factor of MS in such patients.