Endocrine Abstracts

Objective: To study the relationship between regional body fat distribution and homocysteine levels (Hcy) in type 2 diabetes (T2DM) with coronary atherosclerotic lesions and homocysteine (Hcy).

Methods: 115 patients in department of endocrinology and cardiology of Shanxi Province People’s Hospital from October, 2010 to May, 2011 was divided into T2DM with coronary atherosclerosis group 53 patients, T2DM with non-coronary atherosclerosis group 62 patients according to 64 row helical CT coronary imaging and oral glucose tolerance test. Sixty cases of healthy persons setted to the normal control group in our health medical center. There was no statistical difference in age and sex between the three groups by Student’s t-test. Measuring fat mass/height², android/gynoid ratio, trunk leg fat ratio, trunk body fat %, trunk limb fat ratio; Hcy, glycated hemoglobin, fasting insulin, microalbuminuria/creatinine ratio, triglycerides, LDL, HDL, c-reactive protein; metabolic indices and counting insulin resistance index (HOMA-IR); BMI, waist–hip ratio (WHR). Comparing the difference of biochemical index and body fat measurement index in three groups doing the correlation analysis between T2DM with coronary atherosclerotic lesions and Hcy, the correlation analysis between Hcy and body fat index in T2DM with coronary atherosclerosis group.

Results: HOMA-IR, LnHcy have a statistics difference (P<0.05), multiple comparison have a statistics difference (P<0.05) in three groups. Logistic regression analysis shows Hcy is the independent risk factor of T2DM with coronary atherosclerotic lesions. Hcy level of triple vessel lesion group obviously higher than other groups (P<0.05). HOMA-IR, Hcy is independent risk factors of T2DM with coronary atherosclerotic lesions. android:gynoid ratio, trunk leg fat ratio, trunk body fat %, trunk limb fat ratio of T2DM with coronary atherosclerosis group are significantly higher than the rest groups (P<0.05). The four indexes are positively correlated with Hcy level, correlation coefficient is respectively (r=0.640, 0.452, 0.377, 0.323).

Conclusions: Hcy levels are obviously relevant with diabetes cardiovascular disease, Hcy is the independent risk factor of T2DM with coronary atherosclerotic lesions. T2DM with coronary atherosclerosis patients present centripetal fat distribution mode. Hcy is positively related with android/gynoid ratio, trunk leg fat ratio, trunk body fat %, trunk limb fat ratio.

Key Words: type 2 diabetes, diabetic trunk angiopathy, body fat distribution, homocysteine