Endocrine Abstracts

Aim: The aim of this study was to examine the incidence of metabolic abnormalities in adults getting treatments of brain tumors (BT) and acute lymphoblastic leukemia (ALL) in their childhood or adolescence.

Methods: patients were divided in two groups. In group 1: 31 BT survivors (13 women and 18 men) were included. All patients received craniospinal irradiation up to 36 Gy and boost to the tumor up to 55 Gy and chemotherapy. The group 2: 18 ALL survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. The median age was 20 (18; 22) and 20.5 (19; 23), age at the time of treatment – 12 (9; 15) and 7.5 (5; 9), follow-up period was 5 years (2; 10) and 13 years (12; 16) respectively. Metabolic profile was examined.

Results: In the 1st group: we registered elevation of LDL-c (>3.4 mmol/l) in seven patients, both LDL-c and triglycerides (TG) (>1.2 mmol/l) in six. Twelve of them had GH-deficiency, diagnosed with insulin tolerance test. OGTT was performed in 13 patients: FPG=6.1 mmol/l was found in one patient. The median of BMI – 19 (17; 21.8). The BMI correlated with TG (r=0.4, P=0.02).

In the 2nd group: four patients had dyslipidemia: elevation of LDL-c (n=2) and TG (n=2). OGTT was performed in 12 patients, one woman had FPG=6.2 mmol/l in combination with obesity (BMI=49.1 kg/m2). Three patients had obesity. HOMA-index >2.5 was in seven patients. The age at the time of observation was negatively correlated with GH (r=−0.723114, P=0.007872). There were no significant differences in level of metabolic parameters between two groups.

Conclusions: BT survivors showed elevated level of LDL-c in 22.5%, increased of LDL-c and TG in 19.4%. In ALL survivors elevated level of LDL-c and TG was diagnosed in 11.1%. 16% ALL survivors had obesity. There were no abnormalities in carbohydrate metabolism.