Associations between urinary phthalate metabolites and thyroid function: pilot study

Milica Medic-Stojanoska; Natasa Milic; Jovanka Novakovic-Paro; Ivana Bajkin; Tijana Icin; Andrijana Milankov; Djordje Popovic; Branka Kovacev-Zavisic; Nikola Curic

doi:10.1530/endoabs.32.P997

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Endocrine Abstracts (2013) 32 P997 | DOI: 10.1530/endoabs.32.P997

ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)

Associations between urinary phthalate metabolites and thyroid function: pilot study

Milica Medić-Stojanoska ^1, , Nataša Milić ² , Jovanka Novaković-Paro ^1, , Ivana Bajkin ^1, , Tijana Ičin ^1, , Andrijana Milankov ¹ , Djordje Popović ^1, , Branka Kovačev-Zavišić ^1, & Nikola Ćurić ^3,

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Author affiliations

¹Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; ²Department of Pharmacy, Medical School Novi Sad, Novi Sad, Vojvodina, Serbia; ³Institute of Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; ⁴University of Novi Sad Medical School, Novi Sad, Vojvodina, Serbia.

Background: Phthalates presents widespread endocrine disrupting chemicals in many personal-care and consumer products. A limited number of experimental and human studies suggest that exposure to phthalate may be associated with altered thyroid function, but a problem is not elucidated enough. This study focused to examination of the association between urine phthalate metabolites and thyroid function.

Methods: We included 91 healthy person, 47 females and 44 males, mean age 35.91±8.10 years. According to presence (group A) or absence (group B) of urinary phthalate metabolites participants divided in two groups. Free thyroxin (FT₄), free triiodothyronine (FT₃) and thyroid-stimulating hormone (TSH) were measured. Phthalate monoester metabolites (MEP-monoethyl phthalate, MBP-monobuthyl phthalate, MOP-monooctylphthalate, MEHP-mono-(2-ethylhexyl)-phthalate) were measured in single spot urine by mass spectrometry.

Results: In all group values of thyroid hormones and TSH were in normal range (FT₄ 13.41±1.49 pmol/l, FT₃ 5.00±0.64 pmol/l, TSH 1.87±0.98 mIU/l). Urine phthalate metabolite values were: MEP 36.40±137.46; MBP 22.94±118.34; MOP 16.43±102.01; MEHP 44.55±83.30 ng/ml. Significant negative correlation were between FT₄ and MEP (r=−0.214; P<0.05) and significant positive between TSH and MEP (r=0.444; P<0.01). In group A values of FT₄ and FT₃ were slightly decreased and TSH increased than in group B. Urine values of phthalate metabolites in group A were: MEP 71.21±186.65; MBP 22.94±118.34; MOP 16.43±102.01; MEHP 44.55±83.30 ng/ml. Significant negative correlation were found between FT₃ and MEP (r=− 0.300; P<0.05) and borderline between FT₄ and MEP (r=− 0.282; P=0.06). Statically significant positive correlation was between TSH and MEP (r=0.542; P<0.01).