ECE2013 Poster Presentations Bone and Osteoporosis (41 abstracts)
Prospective study of bone mineral density in girls treated with estroprogestagens for functional hypothalamic amenorrhea during late puberty in relation to the polymorphism of VDR (BsmI), ER (PvuII; Xba I), and COLIA1 genes
Elzbieta Sowinska-Przepiera 1, , Elzbieta Andrysiak-Mamos 1 , Grazyna Jarzabek-Bielecka 2 , Justyna Syrenicz 1 , Kornel Chełstowski 3 & Anhelli Syrenicz 1
1Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, Szczecin, Poland; 2Department of Gynecology, University of Medical Sciences, Poznan, Poland; 3Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, Szczecin, Poland.
Introduction: The aim of this study was to verify if genetic factors influence the short- and long-term therapeutic responses to oestroprogestagen (OP) therapy, implemented in girls with functional hypothalamic amenorrhoea (FHA) in order to improve their bone mineral density (BMD).
Material and methods: The study included 84 FHA girls who underwent a 4-year sequential OP therapy with 17-β oestradiol and didrogesterone. Changes in the lumbar spine BMD were determined at the end of the therapy and 6 years after its discontinuation, and analysed in regards to PvuII and XbaI polymorphisms of oestrogen receptor-alpha gene, BsmI polymorphism of vitamin D receptor gene, and Sp1 polymorphism of the type-1 collagen gene.
Results: After 4 years of OP therapy, a significant increase in BMD was documented in the studied group. Follow-up densitometry performed 6 years after completing the therapy revealed a significant decrease in BMD level; nonetheless, the values of this parameter were still significantly higher compared to pretreatment level. Neither the particular polymorphisms nor their combinations influenced the relative change in BMD at the end of the therapy and after a 6-year follow-up.
Conclusions: Variability of genes involved in oestrogen, vitamin D and collagen metabolism does not influence the short- and long-term results of OP therapy in girls with FHA.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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