ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)
Both Graves' disease and toxic nodular goiter are associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study
Frans Brandt 1 , Marianne Thvilum 1 , Dorthe Almind 2 , Kaare Christensen 2 , Anders Green 3 , Laszlo Hegedüs 1 & Thomas Heiberg Brix 1
1Department of Endocrinology and Metabolism, Odense Universitetshospital, Odense C, Denmark; 2The Danish Aging Research Center and The Danish Twin Registry, University of Southern Denmark, Odense C, Denmark; 3Odense Patient data Exploratory Network, Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark.
Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.
Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, respectively, treated in a hospital setting, were identified and followed for a mean period of 11 years. Cases were matched 1:4 with non-hyperthyroid controls with respect to age and sex. The hazard ratio (HR) for mortality was calculated using Cox regression analyses. All analyses were adjusted for co-morbidity, using the Charlson score.
Results: Both GD (HR=1.42, 95% CI 1.25–1.60) and TNG (HR=1.22, 95% CI 1.07–1.40) were associated with increased all-cause mortality. After stratification for the cause of death, GD was associated with increased mortality due to cardiovascular diseases (HR=1.49, 95% CI 1.25–1.77) and lung diseases (HR=1.91, 95% CI 1.37–2.65), whereas TNG was associated with increased cancer mortality (HR=1.36, 95% CI 1.06–1.75). When analyzing mortality in GD using TNG individuals as controls, there was no significant difference in all-cause mortality between GD and TNG. However, GD was clearly associated with a higher cardiovascular mortality (HR=1.39, 95% CI 1.10–1.76) compared to TNG.
Conclusion: Both GD and TNG, treated in a hospital setting, are associated with increased all-cause mortality. The causes of death differ between the two phenotypes with cardiovascular mortality being significantly higher in GD.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more