Endocrine Abstracts

Introduction: The occurrence of a pregnancy in a woman with a corticotroph adenoma is rare, <25 observations have been reported.

Maternal complications are especially hypertension (60–75%) gestational diabetes (25%) and preeclampsia in 10%.

Fetal complications are spontaneous miscarriage, preterm birth and intrauterine growth retardation.

Observation: We report a case of a 30 years old female followed for primary subfertility. The diagnosis of Cushing’s disease is withheld to: obesity, amenorrhea, hypertension and osteoporosis

• Cortisol at midnight=712 nmol/l

• Cortisol at 0800 h=809.4 nmol/l ACTH=9 pg/ml

• Low braking: negative

• Strong braking: positive

• Pituitary MRI: microadenoma 6.4 mm.

Under anti-cortisol arrested 2 weeks later for liver toxicity. The resection of microadenoma was delayed because he was 6 weeks’ pregnant.

Noting a gestational diabetes than the 24^e week. Delivery term.

After 2 years of remission (post resection)a 2nd spontaneous pregnancy with abortion at 12 weeks.

Conclusion: The impact of secretions ACTH of pregnancy requires a multidisciplinary support.