Fetuin-A can be used as a marker of acromegaly

Senay Topsakal; Fulya Akin; Guzin Yaylali; Sebahat Turgut; Duygu Herek; Emrah Yerlikaya; Ceylan Ayada

doi:10.1530/endoabs.32.P935

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Endocrine Abstracts (2013) 32 P935 | DOI: 10.1530/endoabs.32.P935

ECE2013 Poster Presentations Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) (127 abstracts)

Fetuin-A can be used as a marker of acromegaly

Senay Topsakal ¹ , Fulya Akin ¹ , Guzin Yaylali ¹ , Sebahat Turgut ² , Duygu Herek ³ , Emrah Yerlikaya ¹ & Ceylan Ayada ²

Err

Author affiliations

¹Department of Endocrinology, Pamukkale University, Denizli, Turkey; ²Department of Physiology, Pamukkale University, Denizli, Turkey; ³Department of Radiology, Pamukkale University, Denizli, Turkey.

Introduction: Acromegaly is a rare, chronic disorder, with classical clinical features caused by excess GH and consequent raised levels IGF1 and is associated with increased morbidity and mortality. Early diagnosis of the disease is very important for patient survival. Fetuin-A is a plasma glycoprotein that is produced by hepatocytes and it is the most important systemic calcification inhibitor. The physiological importance of fetuin-A, in acromegaly remains obscure. The aim of this study was to investigate the effect of fetuin-A levels on atherosclerotic process in acromegalic patients.

Methods: In this study 37 acromegalic patients and 30 controls were included to the study. Antropometric, biochemical and hematological findings were examined. Height, weight, BMI, and blood pressure of the groups were noted. Fasting blood glucose, lipid profile, GH, IGF1, IGFBP3, TSH, insulin levels were measured. Fetuin-A levels were measured by Elisa method.

Results: We observed significantly higher Fetuin-A levels in acromegalic patients (P<0.001). There was no correlation between fetuin-A and GH, IGFBP3, HOMA, BMI, TG, T. kol, HDL and LDL levels. It was found positive correlation between Fetuin-A andIGF1 levels (P<0.05).

Conclusion: We observed significantly higher fetuin-A levels in acromegalic patients. Our study was the first study that evaluates fetuin-A levels in acromegalic patients. We found positive correlation with fetuin-A and IGF1, in acromegalic patients.