ECE2013 Poster Presentations Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) (127 abstracts)
Evaluation of long-term pituitary functions after hypoxia due to ventricular arrhythmias: a preliminary report
Fatih Tanriverdi 1 , Yasin Simsek 1 , Mehmet Gungor Kaya 2 , Bekir Calapkorur 2 , Halit Diri 1 , Zuleyha Karaca 1 , Kursad Unluhizarci 1 & Fahrettin Kelestimur 1
1Erciyes University Medical School, Kayseri, Turkey; 2Erciyes University Medical School, Department of Cardiology, Kayseri, Turkey.
Introduction: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), stroke and cerebrovascular disease (CVD) are identified as risk factors for hypopituitarism. However, the mechanisms and the risk factors for the hypothalamo-pituitary dysfunction due to TBI, SAH, stroke and CVD are still unclear (1,2,3). Hypoxia, hypoxemia, neuroinflammation, autoimmunity could have impact in the pathogenesis (4). In patients with serious ventricular arrhythmias who need resuscitation, brain tissue may be exposed to short-term severe ischemia and hypoxia. However there are no data in the literature regarding pituitary dysfunction after ventricular arrhythmias.
Materials and methods: Thirty patients with ventricular arrhythmias (25 male, five female) were included in the study. Basal hormone levels were measured. To assess GH – insulin like growth factor (IGF-1) axis glucagon stimulation test was performed and 1 μg ACTH stimulation test was used for assessing hypothalamic–pituitary–adrenal axis.
Results: Four patients had secondary hypogonadism (13.3%). When the two stimulation tests and basal hormone levels were evaluated together no patient had ACTH deficiency, but glucagon stimulation test revealed GH deficiency in 8 of 30 (26.6%) patients. There were no statistical difference according to age, BMI, IGF-1 levels and other hormone levels between GH deficiency and GH sufficient group. However, IGF-1 levels were significantly lower in GH deficiency group.
Discussion: In conclusion, present data clearly suggest that in patients with serious ventricular arrhythmias who need cardiac resuscitation, pituitary dysfunction is not uncommon. Future studies need to be done to understand whether routine screening of pituitary functions in this patient group is clinically relevant or not.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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