ECE2013 Poster Presentations Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) (127 abstracts)
A precocious GH peak at GHRH plus arginine test in GH sufficient short children is predictive of a lower growth velocity
Flavia Prodam 1, , Matteo Castagno 1 , Simonetta Bellone 1, , Giulia Genoni 1 , Enza Giglione 1 , Agostina Marolda 1 , Antonella Petri 1 , Gianluca Aimaretti 1, & Gianni Bona 1
1Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale “Amedeo Avogadro”, Novara, Italy; 2Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale “Amedeo Avogadro”, Novara, Italy.
Introduction: In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.
Subjects and methods: Children who performed a GHRH plus ARG test for short stature were retrospectively recruited. Inclusion criteria were: i) a GH peak >20 ng/ml; ii) Tanner stages within 1–3 stages; iii) 1 year growth velocity (GV) since the test execution; iv) born adequate for gestational age; v) the absence of signs suggestive of syndromes. Primary outcomes were height standard deviation score (SDS), GV, GVSDS and IGF-I SDS.
Results: A 228 subjects were recruited, by which 14 were excluded because they did not satisfy inclusion criteria. Of 214 subjects, 121 (56.5%) had a peak at 45 min, 55 (25.7%) at 30 min, and 38 (17.8%) at 60 min. Subjects presented a peak at 30 min had lower height SDS (P<0.05), GV (P<0.001), GV SDS (P<0.001), and GH peak (P<0.05) than those had a peak at 45 min. Subjects presented a peak at 30 min had lower GV (P<0.001), and GVSDS (P<0.001), but higher GH peak (P<0.05) than those had a peak at 60 min. No differences were shown between children with a peak at 45 or 60 min. No differences in Tanner stages, sex, IGF-I SDS were recorded among three groups.
Conclusion: A peak at 30 min at the GHRH + ARG test in children who are short and without GH deficiency may be predictive of lower GV in the year of the test. Because ARG infusion stops at 30 min, a somatostatinergic higher tone could have a role in the clinical picture.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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