ECE2013 Poster Presentations Paediatric endocrinology (32 abstracts)
Predicting growth response among Egyptian idiopathic isolated GH deficient children
Nermin Salah 1, , Soha Abd El Dayem 1, , Lobna Fawaz 1, & Marwa Ibrahim 1,
1Faculty of medicine, Cairo University, Cairo, Egypt, 2Pediatrics Department, National Research Centre, Cairo, Egypt.
Objective: To determine the Predictors of growth response to GH treatment in a group of isolated idiopathic GH (GH).
Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year up to 6 years. Multiple linear regressions were done to identify predictors of growth response to rhGH in the first 4 years of treatment.
Results: In the first year, three significant predictors of growth were identified: GH peak (ln (μg/l)), age of onset of therapy and target height-height SDS. In the 2nd and 3rd years of therapy, GV was both significantly and positively correlated to the GV (cm/year) of the previous year.
Conclusion: We conclude that, prediction models offer a valuable tool for individualization and assuring adherence to rhGH and thus a cost effective treatment, which is the ultimate goal of GH therapy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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