ECE2013 Poster Presentations Obesity (65 abstracts)
Do the association of phthalates and some parameters of obesity persist? Pilot study
Milica Medić-Stojanoska 1, , Nataša Milić 2 , Bojan Vuković 3, , Dragana Bosić-Živanović 4 , Dragana Tomić-Naglić 1, , Edita Stokić 1, , Damir Benc 1 , Milena Mitrović 1, & Nikola Ćurić 5,
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; 2Department of Pharmacy, Medical School Novi Sad University of Novi Sad, Novi Sad, Vojvodina, Serbia; 3Emergency Center, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; 4Medical Center Ruma, Ruma, Vojvodina, Serbia; 5Institute of Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; 6Medical School, University of Novi Sad, Novi Sad, Vojvodina, Serbia.
Background: Phthalates present endocrine disruptors widely used as plasticisers, solvents and additives in many consumer products. Experimental data and human cross-sectional studies suggest association of phthalates and obesity. This study focused to association between urinary levels of some phthalate metabolites and BMI and waist circumference.
Methods: We recruited 87 obese persons (44 females and 43 males), age 38.57±8.14 years and 103 healthy controls (52 females and 51 males) similar age. Waist circumference was measured and BMI was calculated. Phthalate monoester metabolites (monoethylphthalate (MEP), monobuthylphthalate (MBP), and mono-(2-ethylhexyl) phthalate (MEHP)) were measured in single spot urine by mass spectrometry.
Results: BMI (35.28±8.14 vs 22.85±2.10 kg/m2, P<0.001) and waist circumference (110.85±15.35 vs 78.38±8.03 cm, P<0.001) were significantly higher in obese than in controls. All urinary phthalate metabolites were higher in obese than in controls, but non significant (MEP 52.53±141.89 vs 32.89±128.99; MBP 21.52±134.30 vs 10.25±79.44; MEHP 20.83±56.40 vs 19.90±56.94 ng/ml). There are no any differences in levels urinary phthalate levels between genders in both groups. Only MBP had significant positive correlation with BMI (r=0.201; P<0.05) and waist circumference (r=0.198; P<0.05) in all participants who were positive for urinary phthalate metabolites.
Conclusion: The association between dibutylphthalate (DBP) and some parameters of obesity is possible. Further studies have to confirm and elucidate this association.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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