Do the association of phthalates and some parameters of obesity persist? Pilot study

Milica Medic-Stojanoska; Natasa Milic; Bojan Vukovic; Dragana Bosic-Zivanovic; Dragana Tomic-Naglic; Edita Stokic; Damir Benc; Milena Mitrovic; Nikola Curic

doi:10.1530/endoabs.32.P778

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Endocrine Abstracts (2013) 32 P778 | DOI: 10.1530/endoabs.32.P778

ECE2013 Poster Presentations Obesity (65 abstracts)

Do the association of phthalates and some parameters of obesity persist? Pilot study

Milica Medić-Stojanoska ^1, , Nataša Milić ² , Bojan Vuković ^3, , Dragana Bosić-Živanović ⁴ , Dragana Tomić-Naglić ^1, , Edita Stokić ^1, , Damir Benc ¹ , Milena Mitrović ^1, & Nikola Ćurić ^5,

Err

Author affiliations

¹Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; ²Department of Pharmacy, Medical School Novi Sad University of Novi Sad, Novi Sad, Vojvodina, Serbia; ³Emergency Center, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; ⁴Medical Center Ruma, Ruma, Vojvodina, Serbia; ⁵Institute of Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad, Vojvodina, Serbia; ⁶Medical School, University of Novi Sad, Novi Sad, Vojvodina, Serbia.

Background: Phthalates present endocrine disruptors widely used as plasticisers, solvents and additives in many consumer products. Experimental data and human cross-sectional studies suggest association of phthalates and obesity. This study focused to association between urinary levels of some phthalate metabolites and BMI and waist circumference.

Methods: We recruited 87 obese persons (44 females and 43 males), age 38.57±8.14 years and 103 healthy controls (52 females and 51 males) similar age. Waist circumference was measured and BMI was calculated. Phthalate monoester metabolites (monoethylphthalate (MEP), monobuthylphthalate (MBP), and mono-(2-ethylhexyl) phthalate (MEHP)) were measured in single spot urine by mass spectrometry.

Results: BMI (35.28±8.14 vs 22.85±2.10 kg/m², P<0.001) and waist circumference (110.85±15.35 vs 78.38±8.03 cm, P<0.001) were significantly higher in obese than in controls. All urinary phthalate metabolites were higher in obese than in controls, but non significant (MEP 52.53±141.89 vs 32.89±128.99; MBP 21.52±134.30 vs 10.25±79.44; MEHP 20.83±56.40 vs 19.90±56.94 ng/ml). There are no any differences in levels urinary phthalate levels between genders in both groups. Only MBP had significant positive correlation with BMI (r=0.201; P<0.05) and waist circumference (r=0.198; P<0.05) in all participants who were positive for urinary phthalate metabolites.

Conclusion: The association between dibutylphthalate (DBP) and some parameters of obesity is possible. Further studies have to confirm and elucidate this association.