Endocrine Abstracts

Objectives: Patients with metabolic syndrome who presents with vascular, metabolic or bone disorders of recent onset, or are difficult to control, or are progressively deteriorating is potentially linked to cortisol excess the aim of the study is to evaluate the prevalence of occult CS in metabolic syndrome patients.

Method: In a cross-sectional study, 30 females with metabolic syndrome chosen from Endocrinology Clinic without any phenotypical features of Cushing’s syndrome were subjected to: full history taking,clinical evaluation, BMI, waist circumference, fasting and pp blood sugar, lipid profile and overnight 1 mg dexamethasone suppression test (DST).

Results: Among the 30 patients in the study, three patients (10%) didn’t show positive dexamethasone suppression test (occult Cushing’s syndrome) and the rest of the patients (27) showed positive test

Conclusion: A relatively high prevalence of occult CS was found in our study. Further studies are needed to provide a rationale for systematic screening of occult CS in this population. To be of benefit by reducing the period of time spent in the atherosclerotic, catabolic, and thrombotic milieu of hypercortisolism

Keywords: sub-clinical, Cushing’s, diabetes, metabolic syndrome.