SHBG and testosterone are associated with inflammation in obese men

Jelena Milin-Lazovic; Snezana Polovina; Mirjana Sumarac-Dumanovic; Danica Stamenkovic-Pejkovic; Danka Jeremic; Goran Cvijovic; Svetlana Zoric; Aleksandra Kendereski; Dragan Micic

doi:10.1530/endoabs.32.P761

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Endocrine Abstracts (2013) 32 P761 | DOI: 10.1530/endoabs.32.P761

ECE2013 Poster Presentations Obesity (65 abstracts)

SHBG and testosterone are associated with inflammation in obese men

Jelena Milin-Lazović ^1, , Snežana Polovina ¹ , Mirjana Šumarac-Dumanović ^1, , Danica Stamenković-Pejković ¹ , Danka Jeremić ¹ , Goran Cvijović ^1, , Svetlana Zorić ¹ , Aleksandra Kendereški ^1, & Dragan Micić ^1,

Err

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¹Center for Obesity, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Belgrade, Serbia; ²School of Medicine, University of Belgrade, Belgrade, Serbia.

Introduction: It was showed that low SHBG represent an independent bio-marker of proinflammatory states associated with insulin resistance. Recent studies provide additional evidence that insulin plays no role in decreasing hepatic SHBG production, and that proinflammatory cytokines, contribute indirectly to reducing SHBG expression in liver of obese persons by reducing hepatic HNF-4α. Obesity in men is commonly accompanied by a decline of serum total testosterone and bioavailable testosterone (BT) levels. Metabolic syndrome (MetS) is associated with a further decline in testosterone, independently of BMI and SHBG, with dose-response relationship between decreasing levels of testosterone. Previous reports suggested hypothesis that androgens may have an anti- inflammatory effect. The aim of the study was to examine the association between testosterone and SHBG to C-reactive protein (CRP) and insulin resistance in obese man.

Description of methods/design: We investigated 52 obese man mean age: 38.91±12.56 years; mean BMI: 46.11±10.37 kg/m²) and measured SHBG, testosterone, CRP, fasting plasma glucose, fasting plasma insulin, HOMA-IR and anthropometric measurements (BMI, WC, WHR).

Results: SHBG was significantly inversely correlated with CRP (r=−0.615, P<0.001) and fasting insulin (r=−0.291, P< 0.05). There was no statistically significant correlation between SHBG and fasting plasma glucose, HOMA-IR and BMI< WC, WHR. Levels of testosterone were inversely correlated with CRP (r=−0.341, P<0.05), BMI (r=−0.461, P<0.001) and WC (r=−0.389, P<0.001). There was no statistically significant correlation between testosterone and fasting insulin, fasting glucose, HOMA-IRr or WHR.

Conclusion: Our result suggested association of low levels of testosterone and SHGB with increased inflammation in obese man.