ECE2013 Poster Presentations Obesity (65 abstracts)
The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet
Sonia Pérez Sieira 1, , Gloria Martinez 1 , Begoña Porteiro 1, , Miguel López 1, , Anxo Vidal 1 , Rubén Nogueiras 1, & Carlos Diéguez 1,
1Department of Physiology, School of Medicine–CIMUS, Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain; 2CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Santiago de Compostela, Spain.
Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food intake, energy expenditure, locomotor activity and respiratory quotient) and glucose metabolism (glucose and insulin tolerance tests).
We found that the lack of Nur77 causes a dimorphic response in the metabolic phenotype of mice fed with high fat diet, being the females more sensitive to high fat diet, while male mice lacking Nur77 were similar to their controls. Female Nur77 deficient mice gained more fat mass, an effect that may be explained by the lower energy expenditure in comparison to female wild types. Consistent with the higher amount of fat mass, female Nur77 deficient mice showed a lower insulin sensitivity, with no changes in glucose tolerance.
In conclusion, our findings indicate that Nur77 is a potentially important physiological mediator of body weight and insulin sensitivity, particularly in female mice.
Volume 32
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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