Endocrine Abstracts

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of Vitamin D deficiency and the levels of 25(OH) D and bone profile.

Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2010 and December 2011. We collected information on demographic data, etiological factors for Vitamin D deficiency, clinical presentations (typical and neurological), and radiological findings. T test was used to determine whether there was a correlation between the neurological manifestations of Vitamin D deficiency and vitamin D levels and bone profile. A P-value <0.05 was considered significant.

Results: Sixty patients were enrolled in the study. Atypical presentations included progressive muscle weakness (proximal more than distal) in 73% of the cases and gait disturbances in 61.7% of the patients. There was no significant correlation between neurological manifestations and the bone profile or vitamin D levels. Significant correlations existed only between the inability to walk and the levels of serum calcium and phosphate, with P-values of 0.043 and 0.037, respectively.

Conclusions: Neurological manifestations of Vitamin D deficiency are not correlated with the levels of 25(OH) D or bone profile.

Keywords Vitamin D deficiency, vitamin D, proximal myopathy, bone profile.