Endocrine Abstracts

Introduction: The breast is a hormone-dependent organ.

Purpose: To study hormonal disorders peculiarities and breast diseases in adolescent girls.

Patients and methods: Examined were 867 adolescent girls (aged 12–18), including 154 girls with breast diseases and dysmorphogenies (macromastia, hypoplasia, striae). The questioning, total clinical examination, hormonal analysis and ultrasound examination were conducted. Data are expressed as median.

Results: The investigation shows that 41 (26%) girls had mastopathy (dysplasia), 107 (12%) breast striae, four girls had macromastia, two patients had breast hypoplasia and five adolescent girls had intense permanent mastalgia.

In patients with mastopathy and macromastia estradiol level was 361.3 (136.4; 368.1) pmol/l, LH level was 6.95 (1.1; 30.8) UI/l, ?SH level was 2.57 (0.51; 7.44) mUI/l, insulin level was 26.3 (6.82; 26.8) mcUI/ml, kisspeptin level was 0.05 (0.04; 0.37) ng/ml, testosterone level was 2.0 (0.8; 11.5) pmol/l and progesterone level – 0.43 (0.1; 0.9) nmol/l. The investigation shows that girls with stria cortisol level was 440.5 (175; 589.1) nmol/l. In girls with breast hypoplasia 17-OPH level was 1.17, 0.98, 1.1, 5.6 and 3.3 ng/ml, respectively. In adolescent girls with intense permanent mastalgia prolactin level was from 1022 to 1473 mUI/l. In healthy adolescent girls estradiol level was 150.3 (47.7; 217.8) pmol/l (P=0.01); LH level was 4.2 (1.3; 9.3) UI/l and ?SH level – 1.5 (0.8; 2.04) mUI/l (P=0.03); insulin level was 9.5 (5.9; 16.1) mcUI/ml and kisspeptin level – 0.03 (0.03; 0.06) ng/ml (P<0.01); cortisol level was 231.6 (109.7; 371.1) nmol/l (P=0.01); testosterone level was 0.9 (0.07; 1.2) pmol/l; prolactin level – 245.1 (109.6; 331.4) and progesterone level was 5.23 (2.9; 38.9) nmol/l (P<0.01).

Conclusions: High estradiol, LH, ?SH, insulin, kisspeptin, testosterone, prolactin, 17-OPH and low progesterone level are the most specific hormonal disorders in adolescent girls with mastopathy and breast dysmorphogenies.