ECE2013 Poster Presentations Endocrine tumours and neoplasia (66 abstracts)
Association between expression of Ki-67, parafibromin, p27, and Rb protein and the biological behavior in parathyroid tumors
Keiko Ohkuwa , Chie Masaki , Junko Akaishi , Akifumi Suzuki , Takashi Uruno , Hiroshi Shibuya , Wataru Kitagawa , Mitsuji Nagahama , Kiminori Sugino & Koichi Ito
Ito Hospital, Tokyo, Japan.
Background: Parathyroid carcinoma (PC) is uncommon and occurs in only 1–5% cases of primary hyperparathyroidism. The histological diagnosis of parathyroid tumors can be challenging, and beneficial histological markers are not available for diagnosis or predicting the prognosis of patients. In this study, we investigated the expression of Ki-67, parafibromin, p27, and Rb protein in parathyroid tumors and assessed the correlation between histological diagnosis or prognosis, by using immunohistochemical staining in patients with confirmed PC and parathyroid adenoma.
Methods: Thirty-eight formalin-fixed, paraffin-embedded tissue samples of surgically resected PC (n=18) and parathyroid adenoma (n=20) were studied by immunohistochemical analysis for Ki-67, parafibromin, p27, and Rb expression.
Results: Positive findings were noted for Ki-67 in 11 (61.1%) cases of carcinoma and none of the cases of adenoma (P=0.0002), for parafibromin in one (5.6%) case of carcinoma and 19 (95%) cases of adenoma (P< 0.0001), for p27 in three (16.7%) cases of carcinoma and all cases of adenoma (P< 0.0001), and for Rb in one (5.6%) case of carcinoma and 13 (65.0%) cases of adenoma (P<0.0001). Furthermore, the high rate of Ki-67 expression and the weak immunoreactive expression of parafibromin, p27, and Rb may indicate poor prognosis of PC. These results indicate that the use of Ki-67, parafibromin, p27, and Rb may be helpful in the assessment of parathyroid tumors. Furthermore, the high rate of Ki-67 expression and the weak immunoreactive expression of parafibromin, p27, and Rb may indicate poor prognosis of PC.
Conclusions: These results suggest that Ki-67, parafibromin, p27, and Rb expression may be helpful markers for diagnosis and predicting the clinical outcome of patients with PC.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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