ECE2013 Poster Presentations Diabetes (151 abstracts)
Hypoglycemic evaluation of Swietenia macrophylla King combined seed and endocarp extracts: a comparative study between hot water extraction and aqueous-methanol extraction
Rahim Mhd Noah , Nur Hayati Marican Jaafar , Hanan Kumar Gopalan & Mohamad Rohani Jais
UNIKL Institute of Medical Science, Kajang, Malaysia.
Solvent and process variables were critical to optimize the extractions of potential hypoglycemic compounds within medicinal plants. Hence, the undertaken study was designed to evaluate the hypoglycemic effectiveness exhibited by extraction performed in decoction manner using water as solvent and compares it with an aqueous-methanol solvent extraction. To evaluate the extractions prepared, phytochemical assays and in vivo study in induced-diabetic rats were carried out. Results indicates aqueous-methanol extract as active for alkaloids, flavonoids, cardiac glycosides, reducing sugar, saponins, tannins and terpenoids. It is also more efficient than the hot water extract in improving altered biological parameters impacted by hyperglycemia. As such, aqueous-methanol appears ideal for extracting the necessary potent hypoglycemic compounds within the plant parts studied.
Key Words S. macrophylla King, Hot Water Extract, Aqueous-Methanol Extract, Hypoglycemic.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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