Endocrine Abstracts

Introduction: Diabetic polyneuropathy is detected in 12.5–14.5% of patients after 5 years of falling ill.

Aim: To detect predictors of diabetic polyneuropathy development in prospective parallel open clinical research.

Methods: From 2010 to 2012, 189 patients were examined (108 men, 81 women, average age – 38±7 years) with DM type 2 (82%) and type 1 (18%), without neurological complaints. We estimated the neurological state, detected vibration sensation, tactile sensibility, pain, temperature sensitivity on legs, conducted electroneuromyography. Two subgroups were defined: i) 48 patients with sensory reply amplitude in n. suralis 10-19 mV; ii) 141 patients with sensory reply amplitude in n. suralis <10 mV. The research was conducted twice with a year interval.

Results: In 12 months in 10 cases of the first subgroup (21%) there were complaints of numbness and pains in legs, reduction of achilles reflexes; 10 patients (21%) – reduction of vibration sensation; 1 patient (5%) – pain sensitivity reduction; 1 patient (5%) – temperature sensitivity reduction. In the second subgroup in 12 months later 58 patients (41%) complained of numbness and pains in legs, achilles reflexes reduced (P=0.047); 58 patients (41%) had a reduction of vibration sensation (P=0.047); 15 patients (11%) – tactile sensibility reduction (P=0.025); 18 patients (13%) – an impaired pain sensitivity (P=0.048).

Conclusion: Patients with DM have sensory reply amplitude <10 mV in n. suralis when conducted electroneuromyography which is a predictor of a developing in a year distal sensory diabetic polyneuropathy.