ECE2013 Poster Presentations Diabetes (151 abstracts)
The relationship between glycemic control and BNP levels in diabetic patients
Kursad Dal 1 , Naim Ata 1 , Bunyamin Yavuz 1 , Omer Sen 1 , Guler Kizilca 1 , Zekeriya Akoz 1 , Aslihan Mete Yildirim 1 , Bulent Uygungelen 2 , Kadir Okhan Akin 1 , Esin Beyan 1 & Derun Taner Ertugrul 1
1Teaching and Research Hospital, Ankara, Turkey; 2Andirin State Hospital, Kahramanmaras, Turkey.
Background: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess BNP levels in patients with poor control diabetes before specific treatment for hyperthyroidism and after glycemic regulation was achieved. The study was performed in a prospective design.
Methods: The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, HbA1c, lipid parameters, BNP were measured before the onset of the treatment and after glycemic regulation was achieved.
Results: A significant decrease in BNP (95.0 (4.0–1807) ng/l vs 52.0 (2.1–987.0) ng/l, P<0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r=0.345; P=0.003) and fasting plasma glucose (r=0.366; P=0.002). There was no correlation between the decrease in BNP levels and the lipid parameters (P=NS).
Conclusion: We conclude that poor glycemic control may cause high BNP measurements which can lead to misdiagnosis of congestive heart failure. We suggest that glycosylated hemoglobin and fasting plasma glucose should be checked in patients with high levels of BNP in diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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