Endocrine Abstracts

Aim: To evaluate the adipocins content in the blood with IGT.

Materials and methods: One hundred and one patients with IGT were examined (86 women and 15 men) middle-aged 62.1±1.2 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The anthropometric indications (IMB, WC, and WC/TC), HOMA-IR, insulin, CRP, resistin, leptin, and omentin levels were investigated.

Results: All patients with IGT had IMB more than 30 kg/m², WC in men was higher than 94 sm, in women – 80 sm, that shows that they have visceral obesity type. HOMA-IR, insulin, CRP levels in patients with IGT is actually higher (4.12±0.28, 16.14±0.93 ng/ml and 4.82±0.63 mg/l accordingly) than in control group (1.48±0.11, 7.78±0.43 ng/ml and 2.67±0.56 mg/l accordingly, P<0.001). Resistin level in IGT was statistically higher (9.85±0.41 ng/ml), than in control group (7.46±0.51 ng/ml, P<0.05). The lower omentin content in the patient^'s blood with IGT (271.52±14.92 ng/ml) compared with the control group (395.6±5.3 ng/ml, P<0.001). The leptin content in the men’s blood (12.2±4.5 ng/ml) and IGT women (40.95±3.04 ng/ml) is actually higher than in control group (3.59±0.38 ng/ml in men and 9.56±0.67 ng/ml in women, P<0.001). The leptin level in IGT women positively correlates with IMB (r=0.612, P<0.001), WC (r=0.743, P<0.001), insulin level (r=0.519, P<0.001), HOMA-IR (r=0.496, P<0.001), CRP level (r=0.515, P<0.01), and negatively correlates with omentin level (r=−0.804, P<0.001).

Conclusion: The increase of leptin and resistin levels and reduction of omentin level are noted in IGT in case of having visceral obesity and insulin resistance.