Endocrine Abstracts

Considered are the physiological mechanisms of relationship of the magnitude of blood plasma and interstitial fluid osmolarity conditioned by glycaemia with transmembrane movement of water between intra- and extracellular water compartments of organism. Analysed are the potentialities of impedance spectroscopy in quantitative evaluation of increments of specific volumes of extra- and intracellular fluid of hypoderm tissues occurring due to fluctuations of intercellular fluid glucose level. Substantiated is the possibility of technical implementation of individual systems for non-invasive monitoring of glucose concentration in intercellular fluid on the base of two-frequencies (30 and 1000 kHz) impedancemetry of human skin. Represented are the results of interstitial liquid glucose level calculation performed on the base of transcutaneous measurement of wrist tissues impedance in persons ill with diabetes 1 and 2 and in healthy volunteers. Fulfilled is the comparative analysis of results of glucose level calculation on the base of impedancemetry with the reference data provided by invasive measurements in blood and interstitial liquid by system invasive glucose monitoring Medtronic Guardian Real Time. Revealed is the strong correlation – Pearson’s coefficient is higher than 0.8 – between the results of calculated glucose concentration on the base of impedancemetry and reference data obtained by invasive measurements.