Endocrine Abstracts

Introduction: Inflammatory mechanisms play an important role in the development of cardiovascular diseases and diabetes. Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. Some studies have shown that CCR2 G190A polymorphism might be important for protection of susceptibility to some immunologically-mediated disorders. The aim of our study was to investigate the effect of the CCR2 G190A polymorphism on the development of diabetic coronary heart disease.

Methods: Sixty two diabetic patient with coronary heart disease, 81 diabetic patient without coronary heart disease, and 62 disease-free controls were genotyped. Diabetes was diagnosed according to the criteria of the American Diabetes Association (ADA) and the nondiabetic subjects were selected according to no past history of diabetes mellitus or impaired glucose tolerance. The CCR2 G190A genotype was determined by PCR followed by RFLP.

Results: No significant difference in the frequency of the CCR2 polymorphism between patient groups and the controls was found (P : 0.78 X² 0.48).

Conclusion: In contrast, we did not find any significant difference in CCR2 G190A polymorphism in diabetic patients with coronary heart disease, diabetic patient without coronary heart disease and healty controls