Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum

Athina Gkiomisi; Kali Makedou; Athanasios Anastasilakis; Stergios Polyzos; Anargyros Kourtis; Spyridon Gerou; Elpida Gavana; Themistoklis Dagklis; David Rousso; Charalambos Giannoulis

doi:10.1530/endoabs.32.P370

P370

Prev Next

Section Contents Cite

Endocrine Abstracts (2013) 32 P370 | DOI: 10.1530/endoabs.32.P370

ECE2013 Poster Presentations Diabetes (151 abstracts)

Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum

Athina Gkiomisi ¹ , Kali Makedou ² , Athanasios Anastasilakis ³ , Stergios Polyzos ⁴ , Anargyros Kourtis ² , Spyridon Gerou ⁵ , Elpida Gavana ⁵ , Themistoklis Dagklis ² , David Rousso ² & Charalambos Giannoulis ⁶

Err

Author affiliations

¹Clinic of Obstetrics and Gynaecology, 424 Military Hospital, Thessaloniki, Greece; ²3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece; ³Department of Endocrinology, 424 Military Hospital, Thessaloniki, Greece; ⁴2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Ippokration General Hospita, Thessaloniki, Greece; ⁵Laboratories ‘‘Analysis’’, Thessaloniki, Greece; ⁶2nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM (GDM Group 20 managed with diet only (GDM-diet) and 24 with diet plus insulin (GDM-insulin)) and 44 age-matched pregnant women with normal glucose tolerance (control group) were studied. Serum glucose, lipids, uric acid, insulin, and vaspin were measured at the 2nd and 3rd trimesters of pregnancy and postpartum. The quantitative insulin sensitivity check index (QUICKI) and homeostasis model of assessment-insulin resistance (HOMA-IR) were calculated. Circulating vaspin levels decreased significantly postpartum in all groups (P<0.001), but did not differ between GDM or GDM subgroups and control group in any time point. At the 3rd trimester of pregnancy vaspin was positively correlated to insulin (P=0.022), HOMA-IR (P=0.016) and triglycerides (P=0.033) and negatively correlated to QUICKI (P=0.016) in the GDM women, but not in the Controls. These correlations were not observed at the 2nd trimester or postpartum. Vaspin, in contrast to HOMA-IR, could not independently predict GDM in binary logistic regression. In patients with GDM, insulin treatment did not affect vaspin levels. In conclusion, our data suggest that vaspin levels gradually decrease from the 2nd trimester to postpartum; however, decreases are similar between women with or without GDM. Serum vaspin cannot independently predict GDM and it is not affected by the degree of glucose metabolism deregulation or the exogenous administration of insulin.