ECE2013 Poster Presentations Developmental Endocrinology (14 abstracts)
A study on the relationship between energy reserves and energy expenditure during the time of male puberty
Afzaal Ahmed Naseem 1 , Nadia Afzal 1 , Ayesha Younas 1 , Muhammad Saqlain 1 , Midhat Fatima 1 , Shaista Aslam 2 , Mazhar Qayyum 1 & S S R Rizvi 1,
1Department of Zoology, PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Department of Zoology, Government College University, Lahore, Pakistan; 3Pakistan Science Foundation, Islamabad, Pakistan.
Leptin, a key metabolic signal controlling both energy intake and energy reserves, informs the brain about energy stores of the body to initiate reproductive processes at puberty. Thyroid hormones are important determinant of overall energy expenditure, basal metabolic rate and thermogenesis. The present study examined the relationship between leptin and thyroxine (T4) and triiodothyronine (T3) in boys (n=540) between the age of 1 and 20 years. Blood samples were collected and plasma concentrations of leptin, T4 and T3 were measured using specific ELISA. Data were analyzed using Student’s t-test, ANOVA and Pearson correlation r. Concentrations of leptin increased from 8th year, peaked at 10th year and gradually declined to lowest concentrations at 18th year. Concentrations of T4 were higher at 1st year, increased to highest concentrations at 2nd, declined to lowest level at 4th and rose to peak at 5th year. T4 concentrations declined from 9th year to lower levels between 11th and 13th year, rose to peak at 15th year and declined to lower levels between 16 and 20 years. T3 concentrations exhibited a pleatu from 1 to 3rd year, declined to lowest levels at 4th year and gradually increased at 6th year to be maintained by 8th year. T3 concentrations rose at 9th year, progressively increased to peak at 17 years, slightly declined at 18th years to be maintained by 20th year. Leptin and T4 concentrations were positively correlated at infancy and prepuberty, negatively correlated at early puberty and positively correlated at mid and late puberty/adolescence. Leptin and T3 concentrations were positively correlated at infancy, negatively correlated at prepuberty, positively correlated at early puberty and negatively correlated at mid and late puberty/adolescence. In conclusion, concentrations of leptin, an indicator of energy reserves, are negatively correlated with T3, a marker of energy expenditure at mid and late puberty/adolescence.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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