Vitamin D deficiency predicts incidence of obesity

Inmaculada Gonzalez-Molero; Gemma Rojo; Marta Dominguez-Lopez; Eleazara Rubio; Carolina Gutierrez; Sonsoles Morcillo; Maria Cruz  lmaraz; de Adana Marisol Ruiz; Isabel Esteva; Federico Soriguer

doi:10.1530/endoabs.32.P153

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Endocrine Abstracts (2013) 32 P153 | DOI: 10.1530/endoabs.32.P153

ECE2013 Poster Presentations Calcium and Vitamin D metabolism (62 abstracts)

Vitamin D deficiency predicts incidence of obesity

Inmaculada González-Molero , Gemma Rojo , Marta Domínguez-López , Eleazara Rubio , Carolina Gutierrez , Sonsoles Morcillo , Maria Cruz lmaraz , Marisol Ruiz de Adana , Isabel Esteva & Federico Soriguer

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Endocrinology Service, Carlos Haya Hospital, Málaga, Spain.

Background and aims: To assess the relationship between obesity and the incidence of hypovitaminosis D and investigate the relationship between 25-hydroxyvitamin D levels and incidence of obesity.

Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a standardized clinical examination with an oral glucose tolerance test in those subjects without known diabetes. At the second visit, 25-hydroxyvitamin D levels and iPTH levels were measured.

Results: The prevalence of obesity (BMI ≥30 kg/m²) at the three visits was 28.1, 36.2, and 39.5% respectively. The prevalence of vitamin D deficiency (25-hydroxyvitamin D ≤20 ng/ml) at the second evaluation was 34.7%. Neither obesity at baseline (OR=0.98, 95% CI 0.69–1.40, P=0.93) nor the development of obesity between baseline and the second evaluation (OR=0.80, 95% CI 0.48–1.33, P=0.39) were significantly associated with vitamin D deficiency at the second evaluation. In subjects who were non-obese (BMI <30 kg/m²) at the second evaluation, 25-hydroxyvitaminD values ≤17 ng/ml were significantly associated with an increased risk of developing obesity in the next 4 years (OR=2.35, 95% CI 1.03–5.4, P=0.040).

Conclusions: Vitamin D deficiency is associated with an increased risk of developing obesity.