Association acromegaly and thyroid cancer

Samia Achir; Fella Hasbellaoui; Anissa Khalifa; Mourad Semrouni

doi:10.1530/endoabs.32.P1077

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Endocrine Abstracts (2013) 32 P1077 | DOI: 10.1530/endoabs.32.P1077

ECE2013 Poster Presentations Thyroid cancer (64 abstracts)

Association acromegaly and thyroid cancer

Samia Achir , Fella Hasbellaoui , Anissa Khalifa & Mourad Semrouni

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Department of Endocrinology and Nuclear Medicine, Algiers, Algeria.

Introduction: Acromegaly is a chronic disease caused by hypersecretion of GH and IGF1, it is associated with a high risk of cancer, however the excess incidence of thyroid cancer remains controversial, we report four cases.

Patients and methods: The diagnosis of acromegaly has been placed on a dosage of GH and IGFI, the diagnostic of carcinoma is based on histological study of the surgical specimen.

Results: The sex ♀ predominant (3/4). For three patients (no. 1, no. 2, no. 4) thyroid carcinoma was the mode of revelation of acromegaly. Thyroid hormone function was normal in three quarters of cases. It was a GMN or a united nodular. The FNA made in 50% of cases was contributive in 100%. Papillary form (3/4).

Patient	Sex	Age	Goiter	TSH	FT4	TCT	Cytopunction	Histological type	GH/IGF1
No. 1	♀	34	NTG	NLE	NLE	Nulle	Suspects	Papillary	>50 ng/l per NF
No. 2	♀	39	GMN	NLE	NLE	NLE	–	vesicular	0.42 mui/ml
									219 ng/l
No. 3	♀	51	GMN	BASSE	NLE	NLE	Suspects	Papillary microcarcinoma	41. 3 mui/ml
									1168 ng/l
No. 4	♂	40	NT	NLE	NLE	NLE	–	Papillary	9.5 mui/ml
									217 ng/l

Conclusion: Despite the controversial results regarding the increased risk of thyroid cancer during the acromegaly, the exploring of thyroid is unavoidable and surgery must always be indicated when cytopuncture suspicious or malignant.