Endocrine Abstracts

The diseases of a thyroid gland belong to the most frequent pathology which is met among people. The prevalence and structure of pathology of a thyroid gland, first of all, depends from the level of a iodine status in the population. The first time the assessment of an iodine status in St Petersburg was carried out in 1999 by the staff of faculty therapy of Saint-Petersburg State Medical University named after academician I.P Pavlov. The median urinary iodine concentration was 105 mkg/l. In 2010 the iodine status of St Petersburg was carried out again: the median urinary iodine concentration was significantly higher − 148 mkg/l. In this regard it was reasonable to carry a out comparison of indicators of an iodine status in St Petersburg and the features of a course of a Graves’ disease before the beginning of the actions for the elimination of iodine deficiency (till 1999) and during active iodine prophylaxis.

Materials and methods: There were 310 patients with a Graves’ disease, they were diagnosed during the period from 1970 to 2010.

Results: From 1980 to 2010 the number of remissions of the disease gradually decreased: till 1990 the number of remissions was 21.7% whereas from 2006 to 2011 the remissions were noted at 3.9% of patients with a Graves’ disease. The group of patients with disease recurrence was analysed separately. Till 1990 among the patients with recurrence of a disease developed in 207.00±35.18 months, in the group of the diseased in 1990–1995 – in 73.00±13.95 months, in the group among the diseased in 1996–2000 – in 22.86±3.46 months, in the group 2001–2005 – in 28.59±5.19 month, and in 2006–2011 – in 7.75±1.21 months.

Conclusions: The carried-out research showed that for the last 20 years the essential change of character in the course of a Graves’ disease was noted. It is possible to suppose that the revealed features, most likely are connected with the change of the iodine status of the region.

Keywords: Graves’ disease, iodine deficiency, median urinary iodine concentration, iodine status.