ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)
Correlation between untreated subclinical hypothyroidism, nephropathy and cardiovascular diseases in type 2 diabetic patients
Yllka Themeli 1, , Valbona Bajrami 1 , Lutfie Muka 1 , Myftar Barbullushi 2, , Alma Idrizi 3 , Daniela Teferici 2, & Albana Daka 2,
1DC Ikeda-Euromedica, Tirana, Albania; 2DC Med.al, Tirana, Albania; 3UHC Mother Teresa, Tirana, Albania; 4American Hospital, Tirana, Albania.
Aim: The aim of this study was to determine the relationship between subclinical hypothyroidism and prevalence of nephropathy and cardiovascular disease in type 2 diabetic patients without taking thyroid medication.
Methods: Serum thyrotropin and free thyroxine concentrations were measured in 50 type 2 diabetic subjects in DC ‘Ikeda-Euromedica’ and DC ‘Med.al’ in Tirana, from September 2009 until September 2012. In a cross-sectional study, we examined the prevalence of nephropathy. In a longitudinal study, we examined the risk of cardiovascular disease events, in the 3-year follow-up.
Results: In the cross-sectional analysis, untreated subclinical hypothyroidism was associated with a greater prevalence of diabetic nephropathy (odds ratio, 3.65 [95% CI, 1.36–6.57]) compare to euthyroid diabetics. 10% of all participants developped cardiovascular events. The risk of cardiovascular events was significantly increased in type 2 diabetics with subclinical hypothyroidism after adjustment for age, sex, HbA1c, other standard cardiovascular risk factors and medication (hazard ratio, 2.74; 95% CI, 1.04–7.37; P=0.021), but it became nonsignificant after additional adjustment for urinary albumin-to-creatinine ratio (hazard ratio, 2.13; 95% CI, 0.71–6.40; P=0.217).
Conclusions: Type 2 diabetic patients with untreated subclinical hypothyroidism are associated with an increased risk of nephropathy and cardiovascular events. This fact suggests that the higher cardiovascular events in untreated subclinical hypothyroidism with type 2 diabetes may be mediated with nephropathy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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