Endocrine Abstracts

Introduction: Thyroid and parathyroid pathology may coexist; classically, this is described in multiple endocrine neoplasia. Other nonsyndromic scenarios result in pathologies of these endocrine organs coexisting. The aim of the investigation the chracteristics of thyroid pathology in patients with parathyroid adenoma.

Subjects and method: The study population included 42 (26 patients age <60 years vs 16 patients age ≥60 years) patients with parathyroid adenoma. Clinical presentation, biochemical and radiological details were noted. Concomitant thyroid pathology by neck ultrasonography (US) in all patients.

Results: In patients with age ≥60, levels of PTH and calcium, TSH, free T₃, free T₄, autoantibody against thyroid peroxidase (TPOAb) and autoantibody against thyroglobulin (TgAb) were found to be 169.9±23.7 pg/ml, 11.4±1.1 mg/dl, 4.1±0.9 μIU/ml, 2.4±0.8 pg/ml, 0.91±0.01 ng/dl, 123.7±31.7 IU/ml and 57.0±10.3 IU/ml, respectively. Of the 16 patients, 15 (93.7%) had thyroid nodules. Among 15 patients with thyroid nodules, 1 (6.6%) had malignant thyroid tumor. And also, 7 patients (43.7%) had hashimato thyroiditis. In patients with age <60, levels of PTH and calcium, TSH, free T₃, free T₄, autoantibody against thyroid peroxidase (TPOAb) and autoantibody against thyroglobulin (TgAb) were measured 121.9±34.0 pg/ml, 12.3±2.0 mg/dl, 2.9±0.8 μIU/ml, 2.7±0.9 pg/ml, 1.1±0.1 ng/dl, 190.1±42.9 IU/ml and 76.8±12.1 IU/ml, respectively. Of the 26 patients, 19 (73.0%) had thyroid nodules. Among 19 patients with thyroid nodules, 2 (10.5%) had malignant thyroid tumor. And also, 12 patients (46.1%) had hashimato thyroiditis.

Conclusions: The study was demonstrated that the frequency of thyroide pathologies were high in patients with parathyroid adenoma. And also, the frequency of thyroid nodules were higher in patients with age ≥60 years than thats of patients with age <60 years.