ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)
Graves' disease and cardiovascular risk factors
Carla Brandão 4 , Celestino Neves 1, , Carmo Palmares 2 , Oksana Sokhatska 2 , César Esteves 1, , Camila Dias 3 , Miguel Pereira 1 , Luís Delgado 2, , Davide Carvalho 1, & José Luís Medina 4
1Service of Endocrinology, Diabetes and Metabolism, São João Hospital Centre, Porto, Portugal; 2Department of Immunology, São João Hospital Centre, Porto, Portugal; 3Department of Health information and Decision Sciences, Porto, Portugal; 4Faculty of Medicine, University of Porto, Porto, Portugal.
Objective: To evaluate the interrelationships between Graves’ disease (GD) and cardiovascular risk factors.
Subjects and methods: We analyzed thyroid function tests, anti-thyroid antibodies, BMI, insulin resistance markers, namely homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBISI), insulinogenic index (IGI) and the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein B (ApoB), ApoA1, lipoprotein (a) (Lp[a]), homocysteine, C-reactive protein (CRP), folic acid and vitamin B12, in 106 subjects with GD (51 with overt hyperthyroidim and 55 with euthyroidism). A 75-g OGTT was performed and blood samples were obtained every 30 min for 120 min for measurements of plasma glucose, insulin and C-peptide levels. Statistical analysis was performed with Mann–Whitnney and Spearman’s correlation tests. Results are expressed as mean±S.D. and odds ratio. A two-tailed P<0.05 was considered significant.
Results: 94% of studied subjects were female. Mean age and BMI were similar between both groups. In hyperthyroid subjects, we found significantly higher levels of TRAb (8.3±10.7 vs 2.3±4.8 IU/ml, P<0.001), CRP (0.84±1.55 vs 0.28±0.36 mg/dl, P=0.04), and significantly lower WBISI values (5.01±3.21 vs 6.73±4.23, P=0.02). In the total group, TSH levels were negatively correlated with HOMA-IR (r=−0.22; P<0.05), IGI (r=−0.31; P<0.01) and TRAb levels (r=−0.46; P=0.02). FT3 and FT4 levels were positively correlated with HOMA-IR (r=0.28, P<0.01 and r=0.26, P=0.02, respectively) and negatively correlated with WBISI (r=−0.23; P=0.03 and r=−0.26; P=0.02, respectively). In the euthyroid group, TSH levels were positively correlated with WBISI (r=0.29; P<0.05). In the hyperthyroid group, FT3 levels were negatively correlated with HISI (r=−0.38; P=0.02), and TSH and TRAb were negatively correlated (r=−0.32; P=0.02). Conclusions: The interrelationships between thyroid function, insulin resistance and CRP translate an increased cardiovascular risk in hyperthyroidism due to Graves’ disease.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more