Endocrine Abstracts

Objectives: The aim of study was to examine the levels erythropoietin in hypothyroidism with anemic syndrome of different ages.

Methods: We investigated 52 patients with hypothyroidism with irondeficiency normochromic and hypochromic anemia. Among them were 21 patients between ages from 21 to till 45 years old and 31 over 45 years of age. Examination included total blood, in the blood levels of thyroid hormones, serum iron, erythropoietin, ferritin by standard methods.

Results: As a result it was found that 38% of patients with Hb levels of the blood was below 70 g/l and 62% of patients with Hb levels was below 90 g/l between ages from 21 to till 45 years old. So study revealed that patients over 45 years of age 19% have Hb levels of the blood was below 70 g/l and 81% patients below 90 g/l. The level of erythropoietin in blood plasma in 71% of patients was below 5 ng/ml. At 42% of patients level ferritin was below 20 ng/ml that proves depletion of iron levels. The studying interleukins of patients with hypothyroidism showed an increase in proinflammatory cytokines IFNγ up to 7.15±2.3 pg/ml and IL1β 11.4±5.2 pg/ml that testifies to suppression of the level of erythropoietin by interleukins. In the analysis of thyroid function in patients with hypothyroidism with anemia it was found that the level of TSH was within 23.7±2.8 mIU/ml and free T₄ 7.9±1.3 pg/ml, antibodies to thyroid peroxidase 327.5±62.7 IU/ml.

Conclusion: Thus, in hypothyroidism with anemia, a change of proinflammatory cytokines and decreased levels of erythropoietin and levels. And in patients with hypothyroidism with anemia a younger age discovered severe anemia.