Endocrine Abstracts

Introduction: Thyroid dysfunctions and autoimmunity may concur in the pathogenesis of hemostasis abnormalities. Hashimoto’s thyroiditis (HT) is a frequently chronic autoimmune disease in thyroid gland. The aim of our study were to comparison the hemostatic parameters in patients with HT and control subjects.

Method: A total of 52 women were evaluated. Age, TSH, free T_3, free T₄, anti M, anti Tg, TAFI, TFPI, PAI-1, tPA, PF-4, fibrinogen, plasminogen, protein C and S, freeProtein S, factor V–VII–VIII, vWF, APRC, d-dimer were studied in 34 patients with HT (16 subjects of HT TSH ≥5 mIU/ml, 18 subjects of HT TSH <5 mIU/ml) and 18 controls. Data analysis was performed SPSS. Firstly, HT patients were compared with the control group, then a total of 34 women with HT were divided into two groups according to TSH as TSH <5 and ≥5 mIU/ml.

Results: TFPI (P<0.05) and factor V (P<0.05) were significantly increased in HT patients compared to the controls. PF-4 were lower in patients with HT TSH ≥5 mIU/ml than in patients with HT TSH <5 mIU/ml and controls. No difference were found between the groups with respect to other hemostatic parameters.

Conclusion: Relation between thyroid function and hemostasis has been studied in the last decades. Although the results of studies are still controversial, the reported studies suggest that subclinical hypothyroidism or hyperthyroidism have an increased hypercoagulable state and overt hypothyroidism has a hypocoagulable state. To the best of our knowledge, there is a few study evaluating many of parameters of coagulation-fibrinolysis system in specifical thyroid disease such as HT, Graves’ disease, etc. Therefore, our study may be significant. The results of our study, increased TFPI and factor V, decreased PF-4 in patient with HT, suggest that further studies should be conducted to explain the effect of thyroid functions and its autoimmunity on hemostasis.