ECE2013 Poster Presentations Obesity (65 abstracts)
Serum IL18 concentration is associated with resting energy expenditure independently of BMI
Agnieszka Nikolajuk 1, , Agnieszka Adamska 2 , Monika Karczewska-Kupczewska 2 , Natalia Matulewicz 2 , Magdalena Stefanowicz 2 , Irina Kowalska 2 & Marek Straczkowski 1,
1Department of Prophylaxis of Metabolic Diseases, Polish Academy of Sciences, Olsztyn, Poland; 2Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok, Poland.
Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim of the present study was to estimate the relationship between serum IL18 concentration and resting energy expenditure (REE).
Methods: Our study involved 60 young (age: 23.43±2.62 years), apparently healthy men with normal glucose tolerance. Anthropometric measurements, blood biochemical analysis, euglycemic hyperinsulinemic clamp and indirect calorimetry before and during the clamp were performed in the studied group.
Results: The serum concentrations of IL18 was 259.95±98.36 pg/ml. We found that serum IL18 positively correlated with BMI (r=0.26, P=0.04), fasting serum insulin (r=0.26, P=0.047) and free fatty acids after the clamp (r=0.50, P=0.001). A significant association between basal and post-clamp REE with serum IL18 (r=0.40, P=0.001 and r=0.26, P=0.043, respectively) was observed in the studied group. In multiple regression analysis the relationship between IL18 and REE was independent of BMI (β=0.22, P=0.008).
Conclusion: Our data indicate that serum IL18 concentration is associated with resting energy expenditure independently of BMI.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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