Endocrine Abstracts

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Chronic stress, low socioeconomic status and ingestion of hypercaloric food are all recognized risk factors for obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D). Given the complexity of these metabolic processes and the unavailability of animal models, there is poor understanding of their underlying mechanisms. We established a model of chronic psychosocial stress (CPS) in which animals of low social rank (subordinates, SUB) are vulnerable to weight gain while anim...

Discussion of environmental factors in the development and maintenance of obesity has overwhelmingly focused on the effects of an energy-dense and plentiful food supply and an environment conducive to physical inactivity. In recent years, however, an increased understanding of epigenetics has led to an explosion of interest in the mechanisms through which environmental exposures can exert an influence on energy intake and energy expenditure. Upward trends in domestic winter in...