Endocrine Abstracts

Thyroid malignancies are the most common type of endocrine tumors. Of the various histological sub-types, anaplastic thyroid carcinoma (ATC) represents 2% of all cases but is responsible for most of the thyroid cancer related death.Indeed, ATC is regarded as one of the more aggressive and hard to treat forms of human cancer. Moreover, to date, there is a paucity of relevant models to study how the signature genetic abnormalities detected in ATC contribut...

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Metastatic thyroid cancer that are radioactive iodine-refractory (RAIR) have a high mortality, particularly if positive on [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET). We now have a better understanding of the genetic alterations implicated in the disease. Several studies along the last years have shown that constitutive activation of the mitogen-activated protein kinase (MAPK), triggered by rearrangements of RET and NTRK1 and activating mutations of RAS...