Endocrine Abstracts

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Most pituitary operations for Cushings’s disease are technically difficult procedures. Since the souce of excessive ACTH-secretion in Cushing’s disesase is almost invariably a pituitary microadenoma, selective resection of this minute tumor is considered the primary standard therapy. However, almost half of the tumors escape direct preoperative detection even by sophisticated magnetic resonance imaging. Thus, in these the indication for surgery is based on laboratory...

Surgery remains the first line treatment of Cushing’s disease. However, recent studies based on long term follow-up showed that the risk of late recurrence was close to 20–30% cases, whatever the immediate post-surgical cortisol level. In other cases, surgery is not possible due to contra-indications, or refusal by the patient. Medical treatment is thus of major importance in the management of Cushing’s disease, also taking into account the delay to obtain maxim...