Endocrine Abstracts

Aim/objectives: To investigate relationships between thyroid function, antithyroperoxydase antibodies (ATPO), antithyroglobuline antibodies (ATG) and correlations with echographic pattern in Hashimoto thyroiditis and related diseases.

Materials and methods: Diagnosis: i) ATPO >34 μ/ml=Hashimoto thyroiditis (HT); ii) ATPO=normal with high ATG=thyroiditis with only hyper-ATG (T-ATG). Thyroid function: TSH. Echographic patterns=10 (Peretianu, this Congress). Statistical analysis: linear correlation, χ² tests.

Results: i) ATPO/ATG at onset: a) ATPO: number analysis: HT-1194, T-ATG-80 and average: HT-677.7; S.D.: 1190 (!); T-ATG-11.81. b) ATG in T-ATG: 483.23; S.D.: 852 (!).

ii) Evolutional types for ATPO/ATG: a) all ATPO in HT: no. 2055, av: 740.17 IU/ml. ATPO evolution in HT: undulatorious: 150 (40.31%), decreasing: 156 (40.31%), increasing: 81 (20.93%). b) All ATG in T-ATG: no. 100, av: 415.71. ATG evolution in T-ATG: undulatorious: 4 (18.18%), decreasing: 11 (50.0%), and increasing: 7 (31.82%).

iii) TSH: a) onset HT: av: 8.83 μm/l; b) onset T-ATG: 3.63 μm/l; c) hypothyroidism HT: 41.12%; hypothyroidism T-ATG: 28.7% (χ²=14.44, P=0.044).

iv) Linear correlation ATPO-TSH: a) in HT: HT at onset: r=0.17, P<0.001. All HT values: r=0.11, P<0.001; b) in T-ATG: at onset: r=−0.19, P>0.1 (NS). All T-ATG values: r=−0.17, NS.

v) Echographic pattern 1 vs echographic pattern 8 in HT correlate with ATPO level (Table): χ²>24.9; P<0.001.

Conclusion: i) A certain correlation exists between thyroid function but only for ATPO (not ATG), only in cohorts (not <400 probes), only in HT (not T-ATG): when ATPO increases, thyroid function decreases. ii) HT vs T-ATG evolve with more hypothyroidism. iii) Pattern 8 is related low ATPO levels as compared with pattern 1. Therefore, pattern 1 suggest more inflammation than pattern 8.