Endocrine Abstracts

The aim of our study was to determine the possibility of engraftment and function of the native thyroid tissue in its autotransplantation in the thigh muscle in rabbits. The experiment included 10 animals species Chinchilla Breed at the age of 12–18 months – five females and five males. In order to simulate the animals primary postoperative hypothyroidism animal extrafascial thyroidectomy was performed, and then on the inside of the left thigh of the neurovascular bundle formed femoral canal in the hip adductors, which fits within the thyroid tissue. Thyroid hormone levels before surgery was 1.0485±0.05 pg/ml for T₃ and 1.2082±0.05 pg/ml for T₄. During the first 3 weeks, showed a decline in hormone levels, reaching a minimum for 4th week – 0.8344 and 1.085 pg/ml for T₃ and T₄, respectively. Restoring the original hormone levels was observed in four rabbits, 2 months, in three rabbits – 3 months. Two rabbits were followed for 6 months after surgery, and thyroid hormone levels in 2 months remained above average, slightly decreasing after 3 months. In the early postoperative period (1 week) two rabbits died of pulmonary complications, in the late postoperative period – one (uterine bleeding). The conclusion of the experiment was conducted according to international standards in the period of 3 months (five rabbits) and 6 months (two rabbits). Histological examination of material from the site of transplantation showed a massive proliferation of connective tissue and fat, increased vascularization of the muscles in the area of operation. However, the thyroid tissue not visualized either macroscopically or with standard staining with hematoxylin-eosin and pikrofuksin.