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Endocrine Abstracts (2013) 32 P1034 | DOI: 10.1530/endoabs.32.P1034

ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)

Comparison of pre- and post-levothyroxine hs-CRP and fetuin-A levels in subclinical hypothyroidism

Mehmet Calan 1 , Oktay Bilgir 2 , Ferda Bilgir 3 , Ozlem Calan 2 & Turker Cinali 2

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1Department of Endocrinology and Metabolism, Dokuz Eylul University Medical School, Izmir, Turkey; 2Department of Internal Medicine, Izmir Bozyaka Education and Research Hospital, Bozyaka, Izmir, Turkey; 3Department of Allergy and Immunology, Celal Bayar University Medical School, Manisa, Turkey.

Background: The objective of this trial is to determine pre- and post-levothyroxine treatment levels of inflammation markers, high sensitive-C reactive protein (hs-CRP) and fetuin A in cases with subclinical hypothyroidism.

Material and methods: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for hs-CRP ile fetuin A levels, followed by administration of 50 μg levothyroxine in the patient group for 3 months. During post-treatment stage, hs-CRP and fetuin A levels in the patient group were re-assessed and compared with pre-treatment values.

Results: Pre-treatment levels of both hs-CRP and fetuin A were observed to be higher than the control group. The decrease in hs-CRP levels during post-treatment stage did not reach a statistically significant level (P: 0.440). However, decrease observed in post-treatment fetuin-A levels was found to be statistically significant (P: 0.012).

Conclusion: The decrease in fetuin A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts antiinflammatory and antiapoptotic actions. Even though the decrease in hs-CRP level is statistically insignificant, it is estimated to reach significant levels with sustained treatment.

Keywords: Subclinical hypothyroidism, hs-CRP, fetuin A, levothyroxine.

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Endocrine Abstracts
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