ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)
Vitamin E supplementation in the treatment of Graves' disease
Mirela Sanda Petrulea 1 , Ioana Ilie 1 , Ana Valea 1 , Cristina Ghervan 1 , Carmen Georgescu 1 , Cezar Login 2 , Adriana Muresan 2 & Ileana Duncea 1
1Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Hyperthyroidism in the course of Graves’ disease leads to intensification of oxidative processes resulting in increased oxidative stress.
Objectives: The effect of supplementation with vitamin E was monitored on the speed of attaining euthyroidism and on the oxidative stress parameters in patients with Graves’ disease, treated with thiamazole.
Patients and methods: We examined 43 hyperthyroid patients and 12 euthyroid healthy controls. Patients were divided into two groups according to the treatment: Thiamazole+Metoprolol group and Thiamazole+Metoprolol+vitamin E (Vit E) group. Malondialdehyde (MDA), the marker of lipid peroxidation, carbonyl proteins and reduced glutathion (GSH) were determined from the serum, twice, before the treatment and after 4 weeks of therapy.
Results: Patients who received supplementation with vitamin E in addition to therapy with thiamazole (Group 2) attained euthyroidism faster than the patients treated with only thiamazole (Group 1). The marker of lipid peroxidation, MDA and GSH (reduced glutathione) decreased significantly in the Graves’ disease supplemented patients, compared to those who were treated with thiamazole alone.
Conclusion: The results of the study clearly indicate that supplementation with antioxidants in the treatment of Graves’ disease is justified, particularly those containing vitamin E. Nutritional antioxidants as pharmacological compounds may represent an innovative therapeutic approach to hyperthyroidism as a combined treatment with antithyroid drugs.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more