ECE2013 Poster Presentations Thyroid (non-cancer) (100 abstracts)
Prevalence of thyroiditis in ankylosing spondylitis patients
Korhan Baris Bayram 2 , Ece Harman 1 , Serkan Akcay 3 , Serpil Bal 2 & Banu Arslan 4
1Department of Endocrinology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey; 2Department of Physical Therapy and Rehabilitation, Izmir Ataturk Training and Research Hospital, Izmir, Turkey; 3Department of Orthopedics and Traumatology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey; 4Department of Biochemistry, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
Objective: We aimed to evaluate the prevalance of thyroiditis in ankylosing spondylitis patients in this study. We investigated the role of serum procalcitonin as a chronic inflamatory marker in ankylosing spondylitis.
Methods: Sixty-seven patients who diagnosed as ankylosing spondylitis according to American College of Rheumatology (ACR) criteria and 57 healthy controls were included in our study. Serum levels of procalcitonin, TSH, free triiodothyronine (FT3), free thyroxine (FT4), anti thyroglobulin (anti-TG) and antithyroid peroxidase (anti-TPO) were measured in both groups. The presence of tyroiditis and nodules were evaluated by ultrasonography of the thyroid gland. The disease activity of ankylosing spondylitis were evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).
Results: There were no significant differences in terms of tyroiditis between patient and control groups. It was not detected correlation between serum procalcitonin level and BASDAI in patient group. It was shown that there was no correlation among serum procalcitonin levels, the presence of nodules, and thyroiditis. But, there was a correlation between thyroiditis and serum procalcitonin levels in control group (P<0.05).
| Ankylosing spondylitis group (n=67) | Healthy control group (n=57) | |
| Mean±S.D. | Mean±S.D. | |
| Age (years) | 38.7±10.4 | 38.3±12.0 |
| Gender | ||
| Male (n (%)) | 55 (82.1) | 46 (80.7) |
| Female (n (%)) | 12 (17.9) | 11 (19.3) |
| Tyroiditis | ||
| Present (n (%)) | 23 (34.3) | 13 (22.8) |
| Absent (n (%)) | 44 (65.7) | 44 (77.2) |
| Nodules | ||
| Present (n (%)) | 12 (17.9) | 4 (7) |
| Absent (n (%)) | 55 (82.1) | 53 (93) |
| Procalcitonin levels in patient group with ankylosing spondylitis | P value | Procalcitonin levels in healthy control group | P value | |
| Tyroiditis present | 0.09±0.03 | >0.05 | 0.14±0.03 | 0.004 |
| Tyroiditis absent | 0.08±0.04 | 0.05±0.25 | ||
| Nodules present | 0.09±0.05 | >0.05 | 0.04±0.02 | >0.05 |
| Nodules absent | 0.08±0.03 | 0.07±0.13 |
Conclusion: Although some studies in the literature that showing a significantly higher prevalence of thyroid otoimmunity in patients with spondyloarthritis, we could not show such a relationship in our study. Furthermore, serum procalcitonin concentration was elevated in some cases of tyroiditis. However, it was not shown a relation between procalcitonin and ankylosing spondylitis which was one of chronic inflammatory diseases.
Key words: Ankylosing spondylitis, procalcitonin, thyroiditis.
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