Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2013) 32 P1136 | DOI: 10.1530/endoabs.32.P1136

ECE2013 Poster Presentations Thyroid cancer (64 abstracts)

Thyroglobulin measurement in fine needle aspirates from cervical lymph nodes

Cristina Ribeiro 1 , Sandra Paiva 1 , Miguel Melo 1 , Sofia Gouveia 1 , Fátima Leitão 2 & Francisco Carrilho 1


1Endocrinology, Diabetes and Metabolism Department, Coimbra’s University Hospital, Coimbra, Portugal; 2Clinical Pathology Department, Coimbra’s University Hospital, Coimbra, Portugal.


Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.

Patients and methods: In our department we use this method since 2007. We report seven patients with thyroid disease referred to our department. The ultrasound examination revealed the presence of suspicious cervical lymph nodes. FNAC was performed in the thyroid nodules. The lymph nodes were punction for cytology, together with the TG in the needle washout in the last.

Results: From the patients with high TG, four were already submitted to thyroidectomy, confirming the diagnostic of papillary cancer. Patient 5 has TG antibody elevated, which can contribute to the low level of TG.

PtsLymph node citologyTG (needle)Nodule cytologyGenderAgePrevious cytology
1Th. tumour?24 837 ng/mlInsufficientFemale65Insuf
2Insufficient250 219PapillaryFemale36Coloid
3Insufficient15 999ColoidFemale43Coloid
4Insufficient12 259ColoidFemale34Coloid
5Papillary m48Male19Insuf
6Lymphoma<0.2InsufficientMale36
7Lymphoma<0.2Male28

Conclusion: In these patients, TG in the needle washout in FNAC proved to be a good contribution to the diagnostic of malignancy, making its treatment faster and more efficient. The role of this method is particularly relevant due to the high rate of ‘insufficiency’ in the cytology of lymph nodes (cystic).

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