ECE2013 Poster Presentations Thyroid cancer (64 abstracts)
Incidental thyroid cancer frequency in total thyroidectomy for the graves disease patients and the effect of the presence of nodules on malignity rates
Abbas Ali Tam 1 , Cafer Kaya 1 , Fevzi Balkan 1 , Pamir Eren Ersoy 2 , Samet Yalçin 3 , Gülten Kiyak 2 , Gülnur Güler 4 , Reyhan Ersoy 5 & Bekir Çakir 5
1The Department of Endocrinology and Metabolism Disorders, Atatürk Training and Research Hospital, Ankara, Turkey; 2The Department of General Surgery, Atatürk Training and Research Hospital, Ankara, Turkey; 3The Department of General Surgery, Yildirim Beyazit University, The Center for Health Practice and Research, Ankara, Turkey; 4The Department of Pathology, Yildirim Beyazit University, Medical School, The Center for Health Practice and Research, Ankara, Turkey; 5The Deparment of Endocrinology and Metabolism Disorders, Yildirim Beyazit University, Medical School, The Center for Health Practice and Research, Ankara, Turkey.
Introduction: Our objective for the current review was to inquire the thyroid cancer frequency rate within the patients who have had total thyroidectomy procedure for definitive Graves’ disease treatment and to evaluate the contribution of the presence of nodules to malignity rates.
Materials and methods: The present study was conducted by scanning the data of 214 patients who were applied total thyroidectomy for permanent Graves disease treatment, retrospectively. The participants were assorted into sub groups as benign nodule group, malignant nodule group and no nodule group and afterwards evaluated. The groups were also compared in regards to demographic characteristics and laboratory data.
Findings: Fourteen of the 214 cases were diagnosed with cancer. The malignity prevalence was determined as 6.5%. The sex distributions were found to be statistically similar between the malignant and benign nodule groups (P=0.776). The mean age of the malignant nodule group was significantly higher than the benign nodule group (P=0.042). No significant difference seemed to be between the benign and the malignant nodule group in regards to median TSH receptor antibody levels (P=0.134). The cases were divided into two in regards to nodule presence. Pre-operational USG revealed nodules in 19 cases. Five of these patients had malignity. The malignity frequency was significantly higher in the nodule positive group than the no nodule group (26.3 vs 4.6% relatively, P=0.004). There was also no statistically significant TSH receptor antibody, Anti-TPO antibody titres and thyroid functioning difference between these groups (P>0.05)
Conclusions: We have determined the incidental thyroid cancer frequency in Graves’ disease patients population as 6.5%. Malignity rate grew higher when co-morbid nodules were also present (26.3%). We recommend that when total thyroidectomy patients are the case who is treated surgically for the Graves’ disease, especially if nodules are present, malignity risk must be taken into consideration.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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