ECE2013 Poster Presentations Thyroid cancer (64 abstracts)
Evaluation of whole-body scan, stimulated thyroglobulin after thyroxine withdrawal vs recombinant TSH administration according to the risk groups of tumor recurrence
Mustafa Sahin , Berna Imge Aydogan , Bagdagül Yüksel , Murat Faik Erdogan , Sevim Güllü , Rifat Emral , Demet Çorapçioglu , Nilgün Baskal & Ali Riza Uysal
Department of Endocrinology and Metabolism Diseases, Ankara University Faculty of Medicine, Ankara, Turkey.
Background: Recombinant human thyroid-stimulating hormone (rhTSH)-stimulated serum thyroglobulin (Tg) (s-Tg) and (131)I whole-body scanning (WBS) are supposed to provide equal diagnostic information with thyroxine withdrawal (THW) at follow-up thyroid cancer patients without the symptoms of hypothyroidism. We aimed to compare the WBS and s-Tg levels after thyrogen injection and thyroid hormone withdrawal for tumor recurrence/persistance according to the risk groups.
Methods: The study included 150 patients (119 females, 31 males) prepared to diagnostic WBS with rhTSH or THW. Age, sex, WBS, sTg levels, recurrence and risk groups for tumor recurrence (ATA guidelines 2009) were assesed retrospectively.
Results: WBS was performed with THW in 86 patients and with rhTSH administration in 64 patients. Mean age and sex were not different between the groups.
According to the risk groups for tumor recurrence, 71 patients were in low-risk group. In this group, 39 patients were prepared with THW and 32 patients were prepared with rhTSH for WBS. Mean diagnosis age and RAI doses were not different between the THW and rhTSH groups.
The peak TSH, s-Tg and Anti-Tg were significantly higher after THW compared with rhTSH administration. Both methods were equally effective for detecting metastatic or residual disease in low-risk group.
In moderate–high risk group (n: 79), 47 patients were prepared with THW and 32 patients were prepared with rhTSH for WBS. Mean diagnose age and RAI doses were not different between the groups. The peak TSH, s-Tg and Anti-Tg were also significantly higher after THW compared with rhTSH administration. Both methods were equally effective for detecting metastatic or residual disease in moderate–high risk group.
Conclusion: Both methods were equally effective for detecting metastatic or residual disease.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more